抖阴短视频

header-logo
AdobeStock_214253348
Cell Biology, Neurobiology and Anatomy (CBNA)
Wade W. Sugden, PhD

Wade W. Sugden, PhD

Assistant Professor

Locations

  • Versiti Blood Research Institute
  • 8733 W. Watertown Plank Rd.
    Milwaukee, WI 53226

Contact Information

Education

Postdoc, Boston Children鈥檚 Hospital/Harvard Medical School
PhD, Max Planck Institute for Molecular Biomedicine/University of M眉nster (Germany)
BSC, University of Oregon

Research Interests

Biomechanical forces play a role in shaping and sculpting biological tissues. My laboratory focuses on the development of the blood and vascular systems, paradigmatic tissues where hemodynamics and genetic programs act in tandem to pattern the vascular tree and direct the formation of hematopoietic stem cells from hemogenic endothelium. We pursue these questions primarily in the zebrafish Danio rerio, a genetically tractable vertebrate model in which vascular function and forces can be preserved while experimental and live imaging approaches are conducted. As part of the Hematopoiesis and Immunology Program at the Versiti Blood Research Institute, we benefit from a depth of hematology expertise and we leverage the highly collaborative environment at VBRI/MCW to translate these findings into human and murine models. I take a keen interest in the scientific training and career development of my team. Ongoing projects in the lab aim to decipher the suite of molecular changes induced by hemodynamics in hemogenic endothelium that are responsible for the successful production of hematopoietic stem cells by the endothelial-to-hematopoietic transition.

Publications

  • (Tanaka-Yano M, Sugden WW, Wang D, Badalamenti B, Côté P, Chin D, Goldstein J, George S, Rodrigues-Luiz GF, da Rocha EL, Li H, North TE, Gryder BE, Rowe RG.) bioRxiv. 2025 Jan 23 PMID: 39896635 PMCID: PMC11785177 02/03/2025

  • (Meader E, Walcheck MT, Leder MR, Jing R, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim SE, Daley GQ, Goessling W, North TE.) bioRxiv. 2024 Sep 23 PMID: 39386657 PMCID: PMC11463499 10/10/2024

  • (Lummertz da Rocha E, Kubaczka C, Sugden WW, Najia MA, Jing R, Markel A, LeBlanc ZC, Dos Santos Peixoto R, Falchetti M, Collins JJ, North TE, Daley GQ.) Nat Cell Biol. 2022 Apr;24(4):579-589 PMID: 35414020 PMCID: PMC10123873 04/14/2022

  • (Sugden WW, North TE.) Life (Basel). 2021 Sep 29;11(10) PMID: 34685398 PMCID: PMC8539454 10/24/2021

  • (Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE.) Dev Cell. 2020 Feb 24;52(4):446-460.e5 PMID: 32032546 PMCID: PMC7398148 02/08/2020

  • (Sugden WW, Siekmann AF.) Curr Opin Hematol. 2018 May;25(3):237-244 PMID: 29438260 02/14/2018

  • (Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF.) Nat Cell Biol. 2017 Jun;19(6):653-665 PMID: 28530658 PMCID: PMC5455977 05/23/2017

  • (Sugden WW, Leonardo-Mendonça RC, Acuña-Castroviejo D, Siekmann AF.) PLoS One. 2017;12(8):e0183433 PMID: 28817646 PMCID: PMC5560736 08/18/2017

Publications of from the

© 2025 抖阴短视频.  All rights reserved.  | Terms and Privacy | Web Accessibility Statement

Non-Discrimination, Anti-Harassment, and Legal Compliance Statement
The 抖阴短视频 (抖阴短视频) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, military status, or other legally protected classification. 抖阴短视频 maintains full compliance with all applicable federal, state, and local laws and regulations in pursuit of our missions. Consistent with federal guidance, we affirm our commitment to individual merit, fairness, and equal treatment in all aspects of academic and institutional decision-making.

抖阴短视频's policies, federal and state laws, and regulations prohibit unlawful discrimination and harassment. Employees, learners, students, applicants, or other members of the 抖阴短视频 community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.